Ion-Selective electrodes (ISEs) are routinely used worldwide in clinical chemistry for well over a billion measurements per year. However, the lifetime of these sensors is often limited by lipids and hydrophobic proteins that adsorb onto or are extracted into their polymeric matrixes. Thus, preventing long-term implantation of receptor-based chemical sensors in the human body, and has limited the use of these sensors in the food industry and environmental monitoring.
In our research, we take advantage of the properties of perfluorinated matrixes ((i)chemically very inert, (ii)inhibit cell growth, (iii)have extremely low polarity and polarizability) to develop electrodes with enhanced selectivities, long life-time and wider applications.With our designed fluorophilic ionic additives, we have developed the first electrodes with fluorous phase for cation and anion sensing.
We have also developed the first perflouropolymeric matrix discovering previously unknown fluoropolymer blends. Receptor-doped pH sensors have also been developed. With further optimization, we will design different fluorophilic receptors for other analytes and test these electrodes in real-life samples.
Introdutory Tutorial on Ion-Selective Electrodes!
Philippe Buhlmann's and Li D. Chen's recent review and tutorial: Ion-Selective Electrodes With Ionophore-Doped Sensing Membranes covers topics essential for graduate students or others starting work in the field of ion selective electrodes.